Determination of the Potential Tumor-Suppressive Effects of <i>Gsdme</i> in a Chemically Induced and in a Genetically Modified Intestinal Cancer Mouse Model.

However, this observation seems time dependent, because at 20 weeks there was a strong trend towards more WT mice with moderate inflammation throughout the colon compared to Gsdme KO mice, while at timepoint 22 weeks and 24 weeks there was an inverse trend towards more Gsdme KO mice with moderate inflammation compared to WT mice.

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If we look specifically at inflammation associated with adenocarcinomas, we were able to find a clear trend showing a more severe grade of mononuclear cell infiltration in the Gsdme WT adenocarcinomas when compared to the Gsdme KO adenocarcinomas in the chemical experiment.

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