CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes.

Down‐regulated genes with at least one significantly differentially used exon (1,151 genes) showed a clear trend, with exons up‐regulated at the 5′end and down‐regulated at the 3′end (Fig 6 C).

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However, the distribution of exon usage changes relative to the position of the exon again showed a trend similar to down‐regulated genes with a tendency for down‐regulated exons near the gene 3′ends ( Appendix Fig S8G ).

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This showed a small but highly significant increase of normalized P‐Ser2 occupancy in the gene body and a reduction at gene 3′ends for down‐regulated genes and to a lesser degree for non‐regulated genes ( Appendix Fig S5 ).

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