Coordinate Regulation of Cholesterol and Bile Acid Metabolism by the Clock Modifier Nobiletin in Metabolically Challenged Old Mice.

Elovl6 expression was upregulated at ZT18 by HFD and showed a trend of normalization (reduction) by NOB treatment ( Supplementary Figure S2D ).

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Results at ZT18 showed similar trends but did not reach statistical significance.

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Using ELISA assays, we found that the total serum BA levels increased in the HF group relative to RD; importantly, NOB treatment significantly attenuated the serum BA level at ZT6, and showed a slight trend at ZT18 ( Figure 2 A).

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