Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components.

PLoS One · 2019 · PMC6759151 · PMID 31550275

Europe PMC DOI

hedged sentences

0.0350

closest p · 0.7× alpha

0.0440

boldest claim

The sentences

a negative trendp = 0.035actually significant

By comparing compressed and uncompressed groups, a negative trend was observed in aggrecan expression after compression, except for IL-1β treated samples, where Aggrecan expression was increased (p = 0.035), suggesting once again a counteracting effect of compression on IL-1β effect.

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borderline significancep = 0.044actually significant

A borderline significance was observed by comparing all experimental conditions (Friedman ANOVA test, p = 0.044).

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a clear trendno p-value reported

Anyway, a clear trend of reduced MMP-13 levels in all samples after compression is evident.

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