The efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine with and without primaquine on Plasmodium vivax recurrence: A systematic review and individual patient data meta-analysis.

This difference was apparent despite 37.3% of patients receiving DP doses below those recommended for P . falciparum , with these patients having a 2.5-fold increased rate of recurrence compared with those receiving a higher dose.

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vivax following coadministration of DP and PQ did not reach statistical significance at day 42, this was likely because of the relatively few recurrences at this time following DP alone, because by day 63, the risk of recurrence was reduced by over 90%.

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