Pathophysiologic Mechanisms And Management Of Large Granular Lymphocytic Leukemia Associated Pure Red Cell Aplasia.

20 However, this result did not reach statistical significance, and the survival time was not significantly different between the two groups. 20 The median overall survival of idiopathic PRCA was 212.6 months, and the median overall survival of LGLL-associated PRCA was 147.8 months. 14 Survival time was not significantly different between the idiopathic PRCA and LGLL-associated PRCA.

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Comparing STAT3 mutation(+) LGLL-associated PRCA patients with STAT3 mutation(-) patients, the STAT3 mutation(+) patients had more lymphocytes, more CD8+ T cells 59 and showed a trend towards a younger age (median age, 52.5 years old and 77.5 years old) than the STAT3 mutation(-) patients. 31 LGLL-associated PRCA patients showed a higher frequency of T-cell clonality and STAT3 mutations than PRCA patients without T-LGLL. 59 Some other diseases have been associated with LGLL-associated PRCA: thymoma, 6 , 67 polyglandular autoimmune syndrome, 36 , 68 chronic lymphocytic leukemia, non-Hodgkin lymphoma and amegakaryocytic thrombocytopenicpurpura, 68 , 69 but it is notable that RA and neutropenia were infrequently associated.

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