LPC VEGF-C trap mice showed a reduction of vLV area that was significantly different from LPC control mice in a pairwise Mann–Whitney U-test comparison ( p = 0.0286), but failed to reach statistical significance in a multiple group comparison (Supplementary Fig. 6e ).
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Pairwise Mann–Whitney U test comparison to control mice revealed a significant increase in vLV area after LPC injury ( p = 0.0286), however, this did not reach statistical significance in a mutliple group comparison (Supplementary Fig. 6e ).