showed a trendP = 0.1
Provenzano et al 57 combined GEM with PEGPH20, a drug‐depleting HA, and observed significantly prolonged median survival (median overall survival of GEM‐ (55.5 days) and GEM + PEGPH20 (91.5 days)‐treated mice were significantly different ( P = 0.004); treatment with PEGPH20 alone showed a trend toward increased survival (median = 63 days) that did not reach statistical significance ( P = 0.1)).