Consistent with our previous results, iPSC-derived SNs with WT FUS showed a trend toward decreased tracing over time, which did not reach statistical significance ( Supplementary Figures S2C,D ). iPSC-derived SNs with P525L FUS-eGFP showed a 5-fold decrease in tracing ( p < 0.05, 2way ANOVA, Sidak post-test for multiple comparisons; Supplementary Figures S2C,D ), consistent with the age-dependent neurodegeneration observed in ALS.
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Viral Infections Exacerbate FUS-ALS Phenotypes in iPSC-Derived Spinal Neurons in a Virus Species-Specific Manner.
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