Responsiveness of PROMIS® to change in chronic obstructive pulmonary disease.

We examined whether age, gender, education, physical function and fatigue were associated with dropout and found that only physical function approached significance ( p = .0512).

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Although the effect sizes reflecting change in PROMIS dyspnea severity and functional limitations approached the threshold for small magnitude and did not reach statistical significance in this study, prior cross-sectional studies have provided support for the reliability and validity of these measures in COPD [ 62 , 63 , 78 ] and other chronic lung diseases [ 88 ], suggesting that the small sample size might have limited the responsiveness observed here.

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