Region-specific glucocorticoid receptor promoter methylation has both positive and negative prognostic value in patients with estrogen receptor-positive breast cancer.

Clin Epigenetics · 2019 · PMC6825343 · PMID 31675993

Europe PMC DOI

hedged sentences

0.0640

closest p · 1.3× alpha

0.1410

boldest claim

The sentences

almost reached significanceP = 0.064so close (0.05 < p ≤ 0.1)

Methylation of the C region and lower nodal involvement almost reached significance ( P = 0.064), while L region methylation was associated with both higher pathological stage ( P = 0.013) and higher nodal status ( P = 0.023).

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did not quite reach statistical significanceP = 0.067so close (0.05 < p ≤ 0.1)

A similar trend was observed with respect to the risk of relapse; however, it did not quite reach statistical significance ( P = 0.067).

also in 679 other papers

did not reach statistical significanceP = 0.141not close (p > 0.1)

Although it did not reach statistical significance, there was a trend towards better OS (HR = 0.504, 95% CI 0.203–1.255; P = 0.141) and DFS (HR = 0.559, 95% CI 0.280–1.115; P = 0.099) in the patients with C methylation compared to those with unmethylated C and U regions.

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a negative trendno p-value reported

Results of the Spearman correlation showed that GR expression was significantly inversely correlated with methylation ( P < 0.05) at 19 of 23 proximal promoter CpG sites, and the remainder of probes in the promoter displayed a negative trend (Fig. 1 d).

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