Constitutive or Induced HIF-2 Addiction is Involved in Resistance to Anti-EGFR Treatment and Radiation Therapy in HNSCC.

These relapses had an effect on mice survival ( Figure 5 C): the cetuximab/rapamycin combination was found to result in longer survival compared to the cetuximab/rapamycin/irradiation (close-to-significant difference: p = 0.0648) and to the cetuximab/irradiation (significant difference: p = 0.0015) regimens. 3.

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Treatment of SQ20B and UD-SCC1 cells with cetuximab further reduced clonogenic survival to 32% and 22%, respectively, although the difference did not reach statistical significance in UD-SCC1 cells ( Figure 4 B).

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