DNA Methylation Changes Are Associated With an Incremental Ascent to High Altitude.

low altitude approached significance (β = 0.36 (high), p = 0.096, Supplementary Figure 1B ), and only the comparison between 1,400 m (BL) and 4,240m (day 7) was significant at p <0.05 (β = 0.58, p = 0.033, Table 2 ).

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We also identified associations approaching significance between PPARa methylation and hemoglobin, RXRa methylation and systolic blood pressure, body mass index, and EPO , and mean arterial pressure and EPO methylation ( Supplementary Table 3 ).

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