Systematic screening of 96 <i>Schistosoma mansoni</i> cell-surface and secreted antigens does not identify any strongly protective vaccine candidates in a mouse model of infection.

Finally, antigen 11 appears to be in its own cohort (no other yellow groups) and also seems to be far below the normalised level of 1 - is this actually showing protection? Interesting also that 10 (which showed a trend for protection), and 11 (which looks like it may do also) are both members of the SmLy6 family.

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With the exception of one control animal, which only had a few mature females and therefore had a much lower egg burden, we once again observed a trend towards a reduced number of eggs per gram of liver in animals immunised with protein 10 compared to controls, although this observation did not reach statistical significance ( Figure 5C ).

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