Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro.

COL1A1/COL2A1 ratio did show an increasing trend, concurring with previous reports ( Supplementary data 1 ).

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However, a clear trend of increased COL1A1/COL2A1 ratio could be observed for both groups, with a more intense increase for the untreated condition ( Supplementary data 1 ).

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Real-time reverse transcription-polymerase chain reaction analysis The gene expression of SOX9 displayed a decreasing trend with repeated passages for the non-treated group ( Fig. 2A ).

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ROCKi supplementation did not result in enhanced cell potency with passaging, although a small trend could be observed for ROCKi to maintain expression levels of SOX9 and COL2A1 up to passage 4.

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The addition of ROCKi showed a trend of minimally increased COL2A1, ACAN, and SOX9 expression.

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