ALS patients showed a trend of medullar atrophy compared to healthy controls at their first time point which has reached significance by their second timepoint.
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Brainstem pathology in amyotrophic lateral sclerosis and primary lateral sclerosis: A longitudinal neuroimaging study.
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The sentences
Total brainstem volume reductions in ALS did not reach statistical significance with reference to controls, suggestive of selective medullar and pontine involvement.