Cocaine-induced endocannabinoid signaling mediated by sigma-1 receptors and extracellular vesicle secretion.

In contrast, although 2-AG could be measured in tEV fractions using FTMS in mouse midbrain, and tEV markers were significantly increased after in vivo cocaine treatment, the increase in 2-AG levels produced by cocaine in the tEV preparation did not reach statistical significance despite a clear trend.

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Thus, although a clear trend toward increased 2-AG in these tEV fractions was observed, and cocaine significantly increase midbrain tissue levels of 2-AG ( Figure 5B ), the effect of cocaine on 2-AG content in the tEV fractions was not significant (t 8 = 1.61, p=0.147, unpaired Student’s t-test; Figure 5C ).

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