Potential Interplay between Dietary Saturated Fats and Genetic Variants of the NLRP3 Inflammasome to Modulate Insulin Resistance and Diabetes Risk: Insights from a Meta-Analysis of 19 005 Individuals.

Mol Nutr Food Res · 2019 · PMC6864231 · PMID 31432628

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did not reach statistical significanceno p-value reported

However, these interactions did not reach statistical significance for HOMA‐IR.

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nominally significantno p-value reported

Meta‐analysis of summary results obtained from 19 005 subjects from the CHARGE consortium demonstrates nominally significant interactions between SFA intake and the NLRP3 variant rs12143966 and the OR2B11 rs4925663 variant, to modulate fasting insulin levels.

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highly significantno p-value reported

The rs4925659 variant is located within a strong enhancer region, with highly significant expression quantitative trait loci (eQTL) hits for NLRP3 in human whole blood.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.