British Society of Gastroenterology consensus guidelines on the management of inflammatory bowel disease in adults.

A small double-blind randomised controlled trial of 108 patients with Crohn’s disease treated with 1200 IU daily of oral vitamin D3 or placebo for 1 year just failed to reach significance with 13% in the intervention group versus 29% in the placebo group experiencing a clinical relapse (p=0.06). 907 Small uncontrolled studies show that high-dose vitamin D improves clinical indices in Crohn’s disease. 908 909 Vitamin D status should be routinely measured in IBD and deficiency should

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541 Surgical intervention rates were higher after dilatation of primary strictures, but this did not reach statistical significance.

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Following introduction of a telephone advice line in 2013 in a Scottish hospital, avoidance of consultant clinic and general practitioner appointments were estimated to have resulted in highly significant cost savings of over £42 000 in a 5-month period. 1248 A study in Spain also suggested significant cost savings from availability of telephone consultations with an IBD nurse. 1249 In Canada, a survey of over 1000 patients showed that many felt it difficult contacting their physicians, and 77% stated they would make telephone contact with an IBD nurse if available in future, when having acute symptoms.

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The most recent Cochrane analysis showed a trend towards greater efficacy with higher doses (2 g or more). 108 Rectal 5-ASA is also an effective maintenance therapy for distal ulcerative colitis. 109 110 There are randomised controlled trials evaluating once daily dosing with all the major 5-ASA formulations, and systematic reviews confirm that o

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