Prognostic value of the expression of epithelial cell adhesion molecules in head and neck squamous cell carcinoma treated by definitive radiotherapy.

Likewise, patients treated by concurrent systemic therapy showed a trend toward inferior IFC compared with patients treated with radiotherapy alone (2-year IFC 67.7% vs 84%, respectively, P = 0.055).

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Although it did not reach statistical significance, while only a few patients intensively expressed EpCAM in p16 positive tumors, half of p16 negative tumors intensively expressed EpCAM and it was found that p16 negative tumors were more likely to have p53 mutation, suggesting different carcinogenesis scenarios between p16 positive and negative tumors.

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