VLDL was more rapidly cleared from the plasma after injection to double KO than to ApoE KO mice; this difference, however, did not reach statistical significance ( P < 0.05 n = 6 per group) (Fig. 3 e).
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Deletion of the Mir-106b~ 25 MicroRNA cluster attenuates atherosclerosis in Apolipoprotein E knockout mice.
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In addition, collagen staining showed a trend towards a stable plaque phenotype in the double KO mice.