A preliminary investigation of rare variants associated with genetic risk for PTSD in a natural disaster-exposed adolescent sample.

In analyses predicting diagnostic status, the silent functional class and the nonsense were significantly associated with diagnostic status (corrected sum scores p = .006 and p = .018, respectively), with nominally significant findings in the missense class (combined corrected p = .054).

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groups of highly significant associated variants).

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Lifetime PTSD diagnosis In the analysis with lifetime diagnosis as the phenotype of interest, gene-based sum scores in four genes were significant at the p adj ≤ 0.001 and many more showed a suggestive trend towards significance (see Supplemental Table 2 ).

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