Metabolic Remodeling in the Pressure-Loaded Right Ventricle: Shifts in Glucose and Fatty Acid Metabolism-A Systematic Review and Meta-Analysis.

J Am Heart Assoc · 2019 · PMC6898858 · PMID 31657265

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.1230

boldest claim

The sentences

a negative trendP =0.08so close (0.05 < p ≤ 0.1)

18 , 21 , 27 , 29 , 30 In addition, meta‐regression analysis showed a negative trend with the duration of RV pressure load ( P =0.08) (Figure 3 B).

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did not reach statistical significanceP =0.123not close (p > 0.1)

Glucose oxidation Activity of pyruvate dehydrogenase (PDH), the enzyme converting pyruvate into acetyl‐CoA in the mitochondria, tended to be decreased in RV pressure load but did not reach statistical significance (g=−1.982, P =0.123) 15 , 16 , 18 , 21 (Figure 5 C).

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