Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2.

In addition, three biological pathways (dopaminergic synapse, cAMP signaling pathway, mineral absorption) were nominally significant.

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This finding may be significant as acute alcohol consumption has been shown to suppress parallel fiber long-term depression in the cerebellum, which may contribute to alcohol-induced deficits in motor coordination in rats [ 54 , 55 ].

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While these pathways did not reach statistical significance after correction for multiple comparisons, there is evidence of their potential roles in the relationship between aging and AUD.

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