Clinical Relevance of Genetic Analysis in Patients With Pituitary Adenomas: A Systematic Review.

Front Endocrinol (Lausanne) · 2019 · PMC6914701 · PMID 31920960

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did not reach statistical significanceno p-value reported

Multimodal treatment is needed regularly but comparable with the treatment modalities in non-mutated controls, and difference in disease control did not reach statistical significance ( 9 ).

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showed a trendno p-value reported

One of the largest studies on AIP mutation associated PA (134 cases) showed a trend toward a higher number of treatments in both functioning and non-functioning AIP mutation related PA (median 2 (IQR 1–3)) compared to patients without mutation ( n = 1,271, median 1 (IQR 1–2)) ( P = 0.055) ( 65 ).

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