Longitudinal transcriptome-wide gene expression analysis of sleep deprivation treatment shows involvement of circadian genes and immune pathways.

Transl Psychiatry · 2019 · PMC6920477 · PMID 31852885

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nominally significantno p-value reported

In responders, many significant gene expression changes were observed while in non-responders only a few nominally significant changes were found.

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approaching significanceno p-value reported

The following observation may be of interest: three circadian genes, PER1, CLEC4E and SMAP2 (FDR q = 0.083 approaching significance, 0.048, and 0.039, respectively) showed strong differential gene expression, i.e. increased expression, in responders versus non-responders after SD.

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