Impact of HFE variants and sex in lung cancer.

PLoS One · 2019 · PMC6922424 · PMID 31856248

Europe PMC DOI

hedged sentences

0.0539

closest p · 1.1× alpha

0.0763

boldest claim

The sentences

marginally significantp = 0.0539so close (0.05 < p ≤ 0.1)

When the analysis focused on H63D homozygotes compared to WT HFE patients, the survival difference was marginally significant (p = 0.0539) ( S4A Fig ).

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did not reach statistical significancep = 0.0665so close (0.05 < p ≤ 0.1)

The dramatic difference in survival for male LUSC patients with C282Y HFE compared to WT HFE did not reach statistical significance (p = 0.0665); however, female LUSC patients with C282Y HFE had significantly poorer survival compared to WT HFE (p = 0.0283) ( Fig 4C and 4D ).

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showed a trendp = 0.0763so close (0.05 < p ≤ 0.1)

In TCGA database, the Kaplan-Meier survival curve for lung adenocarcinoma patients showed a trend toward poorer survival in H63D HFE variants compared to WT HFE patients (p = 0.0763) ( Fig 3A ).

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