Effects of the Toll-like receptor 7 (TLR7) agonist, AZD8848, on allergen-induced responses in patients with mild asthma: a double-blind, randomised, parallel-group study.

Respir Res · 2019 · PMC6924002 · PMID 31856838

Europe PMC DOI

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did not reach statistical significancep = 0.076so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

AZD8848 showed a trend towards decreased maximal LAR fall in FEV 1 versus placebo at 1 week after dosing, but this reduction did not reach statistical significance (18% decrease vs placebo; p = 0.076).

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failed to reach significanceno p-value reported

The immunomodulatory effect was detected three weeks after dosing in the final allergen challenge, albeit the effects were much weaker at this time point and failed to reach significance.

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