Barely Significant
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Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial.

Geroscience · 2019 · PMC6925069 · PMID 31761958

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showed a trendno p-value reported
Levels of p21 Cip2 and tp53 were also examined and showed a trend toward reduction in the rapamycin-treated samples, but the changes did not reach statistical significance.

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