The percent TF+ monocytes showed an inverse association with nadir CD4 count that was borderline significant ( P = 0.057: Spearman correlation), whereas no other monocyte markers were associated with clinical or demographic features (data not shown).
CD163 expression was increased only in intermediate and non-classical monocytes ( P = 0.0008 and 0.006, respectively), a trend toward higher TF expression was seen particularly in the classical monocytes ( P = 0.07), whereas PD1 showed a trend toward lower expression mainly in the intermediate and non-classical monocytes ( P = 0.072 for both subsets).
Multiple other soluble factors showed a trend but did not reach statistical significance, which we ascribe to heterogeneity within the HIV subgroup (discussed further, below).