Maternal Envelope gp41 Ectodomain-Specific Antibodies Are Associated With Increased Mother-to-Child Transmission of Human Immunodeficiency Virus-1.

J Infect Dis · 2020 · PMC6935999 · PMID 31504656

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

failed to reach statistical significanceP = .058so close (0.05 < p ≤ 0.1)

Passively acquired IgG binding to these antigens likewise increased risk of transmission but failed to reach statistical significance (ectodomain aOR = 1.03, P = .058; gp140 aOR = 1.02, P = .071; gp41 aOR = 1.04; P = .08).

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showed a trendno p-value reported

A fourth antigen, 6-Helix, containing NHR and CHR regions linked in trimeric form, showed a trend for an association with MTCT for maternal plasma antibody binding.

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