High-Fat Diet-Induced Obesity Causes Sex-Specific Deficits in Adult Hippocampal Neurogenesis in Mice.

In females, both CD68 + area and percentage area positive for colocalized Iba1 and CD68 (absolute microglial phagocytic activity) were positively correlated with the number of Ki67 + and DCX + cells in the whole hippocampus and dorsal subregion, though most of these associations did not reach statistical significance; such correlations were not apparent in the ventral subregion in females ( p > 0.05 for all).

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There were also positive correlations in males between metabolic outcomes and CD68 + area, and metabolic outcomes with percentage area positive for colocalized Iba1 and CD68 (absolute microglial phagocytic activity) in the whole hippocampus and dorsal and ventral subregions ( r = 0.32-0.49), though most of these relationships failed to reach statistical significance.

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