Overexpression of mitochondrial creatine kinase preserves cardiac energetics without ameliorating murine chronic heart failure.

1 ) show a strong trend for improved survival in the OE mice compared to WT (3 deaths from n = 30 OE mice vs. 9 deaths from n = 33 WT, P = 0.08), in particular, within the first 10 days post-surgery.

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There was a clear trend towards improved early survival in the Mt-CK-OE mice (90% vs. 73% for WT), which can be attributed to a higher incidence of heart failure in WT during the first 10 days.

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This did not quite reach statistical significance, in part, because mortality in the WT group was relatively low (cf.

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