Exploring the Novel Susceptibility Gene Variants for Primary Open-Angle Glaucoma in East Asian Cohorts: The GLAU-GENDISK Study.

Sci Rep · 2020 · PMC6959350 · PMID 31937794

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closest p · 0.0× alpha

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boldest claim

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nominally significantP = 2E–06actually significant

SNP rs116121322 in LRRC27 showed nominally significant association with POAG in the discovery cohort (OR = 29.85, P = 2E–06).

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did not reach statistical significanceno p-value reported

Additionally, nominally significant associations were observed for rs116121322 (OR = 29.85, P = 2.2E–06) in LRRC27 , rs191590289 (OR = 3.42, P = 6.9E–06) in METTL20 , rs140732889 (OR = 20.72, P = 5.1E–05) in ZNF677 , and rs4889261 (OR = 0.33, P = 5.4E–05) and rs13339342 (OR = 0.34, P = 37.8E–05) in PKDIL2 ; however these associations did not reach statistical significance after Bonferroni corrections for multiple testing (Table 3 , Supplementary Material Table S1 , and Fig. 1 ).

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marginal significanceno p-value reported

The SNPs rs4889261 (OR combined = 0.35, adjusted P = 0.013) and rs13339342 (OR combined = 0.36, adjusted P = 0.013) in PKD1L2 showed only marginal significance from combined analysis of entire Korean cohorts (Supplementary Material Table S2 ).

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