Increased inflammatory lipid metabolism and anaplerotic mitochondrial activation follow acquired resistance to vemurafenib in BRAF-mutant melanoma cells.

Br J Cancer · 2020 · PMC6964672 · PMID 31819183

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0.1000

closest p · 2.0× alpha

0.1000

boldest claim

The sentences

did not reach statistical significancep = 0.1so close (0.05 < p ≤ 0.1)

There was a trend towards decreased vemurafenib GI 50 values with gefitinib treatment in R6-resistant cells, but this did not reach statistical significance ( p = 0.1, Fig. 3d ).

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showed a trendno p-value reported

Other metabolites such as alanine or glycine showed a trend towards a decrease in R6 cells but data dispersion within groups, probably due to the lower SNR related to the NMR signal of those metabolites, was too high to reach statistical significance (Fig.

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