B Cell and CD4 T Cell Interactions Promote Development of Atherosclerosis.

When comparing with PBS transfer group, total IgM levels in WT B cell transfer group was increased, however CD40-deficient B2 cell transfer groups had increased total IgM levels that failed to reach statistical significance ( p = 0.0757) ( Figure 5A ).

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In contrast, despite having B cells detected ( Figure 3A ), comparable body weights (data not shown) and plasma lipids ( Figure S5 ), while atherosclerosis was an increasing trend with mice that received MHCII −/− and CD40 −/− B cells, it did not reach statistical significance ( Figure 3B ).

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