A prior history of binge-drinking increases sensitivity to the motivational valence of methamphetamine in female C57BL/6J mice.

Subst Abuse · 2020 · PMC6971957 · PMID 32009790

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significanceP = .06so close (0.05 < p ≤ 0.1)

Although a visual inspection of the shape of the MA dose-conditioning function in alcohol-experienced males appeared to be quite different from that of females (particularly at the 4.0 mg/kg MA-conditioning dose; Figure 6 ), all of the other interactions with the Sex factor did not reach statistical significance [Sex × History: F(1,186) = 3.67, P = .06; Sex × Dose: F(4,186) = 2.31, P = .06].

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difference was apparentno p-value reported

No statistically significant sex difference was apparent for the potentiation of MA-conditioned reward produced by prior binge-drinking history.

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