Impaired Glucocorticoid Receptor Dimerization Aggravates LPS-Induced Circulatory and Pulmonary Dysfunction.

In accordance with this, GR dim/dim mice with increased levels of Opn showed a trend toward reduced Il-10 mRNA expression in the lung compared to GR +/+ mice during PBS and LPS-challenge ( Figure 5D ).

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This reduced lung compliance was accompanied by a clear trend toward an increased albumin extravasation in GR dim/dim mice after LPS-challenge ( Figure 4B ), indicating an impaired lung barrier function.

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