Detection of suspicious interactions of spiking covariates in methylation data.

Hence, we will say that there is a clinical relevant effect, if a significant trend can be observed.

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If a negative trend of the covariate can be observed and the β 0 coefficient of the linear regression is greater than Q 3 , again, a suspicious interaction can be observed.

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One of the interactions depicted in column four ( φ = −1) is feasible if the covariate shows a decreasing trend.

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