PREX1 drives spontaneous bone dissemination of ER+ breast cancer cells.

In contrast, dissemination to the lung was reduced in the MCF7b-inoculated group, although this did not reach statistical significance ( Fig. 3H and Fig.

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These results suggest that PREX1 upregulation or other molecular alterations harbored by MCF7b cells may not drive spontaneous progression and outgrowth of bone-disseminated tumor cells into overt bone metastases, but rather prime MCF7b cells to leave the primary tumor site; however, it is notable that lesion area approached significance in the intracardiac-inoculated model ( Fig. 3J ).

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