Nanocatalytic activity of clean-surfaced, faceted nanocrystalline gold enhances remyelination in animal models of multiple sclerosis.

Using this approach, we found that a highly significant overrepresented upregulated pathway (p = 6.50E-04) was the Hsf1 ( heat shock factor 1 )-dependent transactivation pathway, with the following twenty upregulated transcripts supporting this pathway enrichment, including: Akt1s1 , Rptor , Tnfrsf21 , Serpinh1 , Hspa1b , Hspa1a , Col4a6 , Fkbp4 , Cryab , Mtor , Camk2b , Hsf1 , Ubb , Mlst8 , Hspb8 , Hspb1 , Hspb2 , Slc29a1 , Hspa2 , Dedd2 .

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An increase in myelinated axons was also observed for animals in the prophylactic arm with CNM-Au8 administered by gavage; however, this trend did not reach statistical significance when corrections for multiple comparisons were applied (Fig. 2 , light green circles).

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There was a statistically significant improvement in central vertical rearing counts (p < 0.05), and near-significant trends in central path length and vertical rearing counts (Fig. 4b ).

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