DRD4 48 bp multiallelic variants as age-population-specific biomarkers in attention-deficit/hyperactivity disorder.

According to the brain tissues filter, the analysis showed a nominally significant association ( P < 0.05) with DRD4 due to a downregulation of gene expression in a specific brain area, which is the Putamen region included in Basal Ganglia ( Z -score = −3.02, P = 0.00252).

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In particular, the homozygous 4R genotype demonstrated an association with improved MPH response, when compared with other genotypes (OR: 1.66, 95%CI: 1.16–2.37, P = 0.005), whereas the meta-analysis of the 7R repeat allele versus others showed a trend with an OR = 0.68 (95%CI: 0.47–1.00, P = 0.05) 38 .

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