Elevated Levels of Interleukin-27 in Early Life Compromise Protective Immunity in a Mouse Model of Gram-Negative Neonatal Sepsis.

Additionally, increased production of IL-27 in Gr-1 + and F4/80 + cells at 24 h was trending toward and nearly statistically significant ( Fig. 2E ).

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In the blood, only CD115 + and F4/80 + cells increased IL-27 production at either time point during infection, although these changes did not reach statistical significance ( Fig. 3C and E ).

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When the change in weight was expressed relative to the control pups in each group, a highly significant improvement in weight gain was evident in IL-27Rα −/− neonates ( Fig. 4C ).

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