<i>In vivo</i> protective effect of adipsin-deficiency on spontaneous knee osteoarthritis in aging mice.

Aging (Albany NY) · 2020 · PMC7041762 · PMID 32012117

Europe PMC DOI

hedged sentences

0.1330

closest p · 2.7× alpha

0.1330

boldest claim

The sentences

did not reach statistical significancep=0.133not close (p > 0.1)

Adiponectin expression was also increased but did not reach statistical significance (11.77±13.99, p=0.133).

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showed a trendno p-value reported

Among the two inflammatory factors, only IL-6 showed a trend toward lower levels in the Df -/- mice at both time points.

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did not quite reach statistical significanceno p-value reported

Moreover, the beneficial effect of FGF-21 in the protection of the articulation against OA development/progression in the adipsin-deficient mice could also be due to the fact that FGF-21 inhibits IL-6 [ 55 ]; an inflammatory factor that, although it did not quite reach statistical significance, showed a trend toward a lower serum level in the Df -/- than the Df +/+ mice in young mice, and was statistically different when compared to Df +/+ (L) mice.

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