Behavioral Alterations in Mice Carrying Homozygous <i>HDAC4</i> ^<i>A778T</i> Missense Mutation Associated With Eating Disorder.

For EPM, homozygous male mice spend less time on open arms compared to their WT littermates (by Student t -test, t (29) = 2.27, p = 0.0154, Figure 2A ), while homozygous female mice tend to spend more time on open arms though it did not reach statistical significance ( Figure 1B ).

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When fed high-fat diet, male, but not female, homozygous mice showed a trend toward decreased weight gain compared to their wild-type littermates.

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