No association of complement mannose-binding lectin deficiency with cardiovascular disease in patients with Systemic Lupus Erythematosus.

In a first exploratory analysis of 177 SLE patients, a strong trend towards a significant difference in plasma MBL concentrations between patients with and without CVD was observed.

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Risk stratification of CVD with potential confounders Adjusting the risk of CVD for MBL levels, potential and traditional CV risk factors, revealed a significant association of CVD with male sex (p = 0.05), age (p < 0.001), disease duration (p < 0.001), APL+ (p < 0.001), hypertension (p < 0.001), hypercholesterolemia (p < 0.001) and history of smoking (p = 0.02) in the univariate analysis, while the association with MBL levels p = 0.34), disease activity (SLEDAI p = 0.9, PGA p = 0.56), BMI (p = 0.58) and DM (p = 0.12) did not reach statistical significance.

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