Role of the DNA repair genes <i>H2AX</i> and <i>HMGB1</i> in human fat distribution and lipid profiles.

BMJ Open Diabetes Res Care · 2020 · PMC7050360 · PMID 32114485

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0.0680

closest p · 1.4× alpha

0.0680

boldest claim

The sentences

did not reach statistical significancep=0.068so close (0.05 < p ≤ 0.1)

Indeed, we found that homozygous and heterozygous carriers of the A-allele of rs7350 show decreased DNA promoter methylation levels in SAT which, however, did not reach statistical significance (p=0.068; online supplementary table 2 ).

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nominally significantno p-value reported

Additionally, A-allele carriers of rs7530 show a nominally significant reduction in HMGB1 mRNA expression in SAT ( online supplementary figure 3 ). 10.1136/bmjdrc-2019-000831.supp4 Supplementary data Associations of H2AX and HMGB1 expression/methylation with clinically relevant parameters of obesity To understand the potential role of differentially regulated DNA repair genes in obesity, we conducted correlation analyses between gene expression and DNA methylation with clinically relevant obesity traits.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.