Oncolytic poxvirus CF33-hNIS-ΔF14.5 favorably modulates tumor immune microenvironment and works synergistically with anti-PD-L1 antibody in a triple-negative breast cancer model.

Oncoimmunology · 2020 · PMC7051185 · PMID 32158622

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showed a trendno p-value reported

CF33-hNIS-ΔF14.5-treated tumors showed a trend of higher IFNγ+ CD8 + T cells however this increase did not reach statistical significance compared to PBS-treated tumors.

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did not reach statistical significanceno p-value reported

In terms of survival, only the combination treatment significantly increased survival of mice compared to PBS-treated mice whereas survival benefits for mice treated with single agents did not reach statistical significance ( Figure 3(c )).

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