Digoxin-amiodarone Combination is Associated With Excess All-cause Mortality in Patients With Atrial Fibrillation.

Sci Rep · 2020 · PMC7058044 · PMID 32139765

Europe PMC DOI

hedged sentences

0.0680

closest p · 1.4× alpha

0.0680

boldest claim

The sentences

did not reach statistical significanceP = 0.068so close (0.05 < p ≤ 0.1)

There was a trend of increased SCD rate in combination group but did not reach statistical significance (8.2% vs. 10.0%, P = 0.068).

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showed a trendno p-value reported

Animal and cohort study both showed that amiodarone could increase serum digoxin level, digoxin bioavailability, and showed a trend to prolong digoxin elimination half-life and decreased its renal clearance 23 – 26 .

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