Effectiveness of AbobotulinumtoxinA in Post-stroke Upper Limb Spasticity in Relation to Timing of Treatment.

Although reductions in MAS scores descriptively favored the early treatment group, the difference compared to the late group did not reach statistical significance at the last study visit (ANCOVA: difference in adjusted means of 0.15, p = 0.546).

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Whereas, patients in the early-start group showed a trend to reduced pain, and particularly over the first injection cycle, patients in the late-start group reported relatively stable pain scores over time ( Figure 3A ).

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